Endocrine Abstracts

Introduction: Persistent or intermittent postoperative discordance between growth hormone (GH) after OGTT and insulin-like growth factor-1 adjusted for age and gender (IGF-1) is up to 39% according to different studies. The aim of this study was to evaluate the impact of this discrepancy (normal GH and elevated IGF1 or vice versa) over the risk of biochemical and tumour recurrence after initial successful surgery for acromegaly.Methods: In this retrospec...

Introduction: Rare cases of pheochromocytoma are associated with stress induced Takotsubo cardiomyopathy explained by high catecholamine exposure causing microvascular spasm and direct myocardial impact.Case report: A 49-year-old female with a history of poorly controlled hypertension, with paroxysmal elevations in blood pressure and rare supraventricular extrasystoles, lipothymic events, was firstly assessed in the cardiologic department. She presented ...

Resistance to thyroid hormones (RTH) is a genetic syndrome characterized by reduced responsiveness of target tissues to thyroid hormones (TH) and accompanied by normal or slightly high TSH values with high serum concentrations of fT4 or fT3. We present two cases of RTH, one pituitary and one generalised resistance.Case 1: A 31 y.o. male presented with thyrotoxicosis symptoms and a biochemical profile showing increased serum fT4...

A rare and aggressive form of thyroid malignancy, medullary thyroid carcinoma (MTC) is virtually incurable except by complete surgical resection. Due to its insidious onset and extensive spread at diagnosis, its prognosis is often poor.Aim: To evaluate treatment outcome and prognosis in patients diagnosed with MTC admitted to our department between 2004 and 2013.Patients and methods: We identified 21 patients (eight men and 13 wome...

A 42-years woman presented with hypothyroidism, a large, firm, irregular goiter, severe cervical and preauricular pain, 2 weeks after an episode of respiratory infection. Laboratory findings certified subacute thyroiditis and autoimmune hypothyrodism: TSH>50 μUI/ml, FT4=6.5 pmol/l, ATPO>1000 U/ml, ATGL>1000 U/ml, ESR=115 mm/1 h. Thyroid ultrasound showed hypoechogenic pattern with a nodule on the right lobe and low Doppler signal. Fine needle aspira...

Despite rarer in children than in adults, GH-secreting pituitary adenomas are often more aggressive, being challenging cases during childhood. Somatic changes (tall stature and acromegalic features), optic chiasma syndrome or metabolic and cardiovascular impact of GH excess trigger diagnosis and requires aggressive management. Treatment options are surgery, radiotherapy and medical therapy using somatostatin analogues, dopamine agonists and recently, GH receptor antagonists &#...

Introduction: Pheochromocytomas and paragangliomas (PPGLs) are rare tumors of the chromaffin tissue characterised by catecholamine excess. Cardiovascular complications, such as hypertensive crisis and catecholamine-induced cardiomyopathy, are known to be the most frequent causes of life-threatening events in PPGLs patients.Design: We analysed records of patients diagnosed with PPGLs in one referral centre from Romania between 1976 and 2021 (n= 1...

Introduction: Graves’ disease (GD) is an autoimmune disorder causing hyperthyroidism. Variations of functional profile as well as type and titer of thyroid specific antibodies makes the control often difficult. One treatment option is adding levothyroxine to anti-thyroid drugs (ATDs), so-called block-replace therapy (BRT).Aim: To study the BRT impact on lipid profile, thyroid function tests (TFTs) and TSH receptor antibodies (TRAb). <p class="ab...

Introduction: Medullary thyroid cancer (MTC) is a neuroendocrine tumor of the parafollicular or C cells of the thyroid gland. While thyroid cancer is increasingly common worldwide, MTC still has a low incidence. We present a case of a seventy-one-years-old woman who presented in our unit after an axillary adenopathy biopsy which tested sparsely positive for KeratinPan, CK7, CEA, TTF1, Chromogranin, Snaptophysin and calcitonin, focal positive for EMA, PAX8, Ki67 30%. Also multi...

Background: Matrix metalloproteinase-9 (MMP-9) is overexpressed in almost all human cancers (including thyroid). High serum levels are generally associated with an adverse prognosis, although the evidence related to thyroid cancer is still controversial.Aim: We aimed to evaluate pre- and post-surgical serum MMP-9 levels for its diagnostic and prognostic value in a series of patients with benign thyroid disease (BD) or differentiated thyroid carcinoma (DT...